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Future breakthroughs can rely on three aspects: precise identification of IDO1-dependent AML subpopulations (such as single-cell sequencing to analyze IDO1 + cell clusters), development of novel metabolic intervention strategies (such as regulating the availability of tryptophan through gut microbiota), and exploration of time-dependent dosing regimens (such as first targeting leukemia cells and then reversing immunosuppression)

Refuerzo al metabolismo

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▪ Combination rationale: The 1:1 pairing is proposed to act through complementary repair pathways — a hypothesis, not a proven synergy