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*Correspondence: Anand Thirupathi, [email protected] Gu, [email protected] This article was submitted to Oxidant Physiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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While mitochondria play a critical role in ATP production, electrons can leak from the electron-transport chain during oxidative phosphorylation and react with oxygen, forming ROS, which, if accumulated in excess, can lead to cellular damage [67,68,87,88]

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