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Ref.: Imai & Guarente, Trends Cell Biol 2014 | Katsyuba et al., Nat Metab 2020 Glutathione is an endogenous tripeptide (gamma-Glu-Cys-Gly) and the main intracellular antioxidant in the human body

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The peptide’s ability to produce metabolic effects with such rapid plasma clearance (3-minute half-life) while maintaining prolonged biological activity represents a significant knowledge gap requiring further investigation