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[DOI] [PubMed] [Google Scholar] 344.Eizirik DL, Delaney CA, Green MH, Cunningham JM, Thorpe JR, Pipeleers DG, Hellerstrom C, Green IC

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Cellular experiments show that SEM treatment significantly increases the expressions of β3-AR and protein kinase A (PKA) in mature 3T3-L1 cells, followed by upregulation of mitochondrial biogenesis markers, PGC-1α, NRF1, and TFAM, a significant reduction in mitophagy-associated markers, PINK1 and Parkin, increase the protein level of p62, and upregulate mRNA and protein expressions of Ucp1, suggesting that SEM can induce mitochondrial biogenesis, inhibit mitophagy, and promote browning of white adipocytes by activating the β3-AR/PKA pathway (Lin et al., 2021)