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Interestingly, untreated NRF2-KD cells had significantly lower serine, glycine and glutamate levels, suggesting that NRF2 plays a crucial role in regulating baseline serine/glycine/glutamate levels

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Mothers should ensure vitamin B12 sufficiency before they are pregnant, however, if this is not possible, urinary Organic Acids Testing should be carried out to establish sufficiency, and cases of deficiency mothers should supplement not only with vitamin B12, but also with Iodine, Selenium, Molybdenum and vitamin B2 if there is reason to believe that these may also be deficient