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This suggests that the reduction in GPX4 may mediate ferroptosis in some nigral neurons during PD progression, while the elevated GPX4 in surviving neurons represents a protective response against oxidative stress and neurodegeneration

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Plumbagin (5-hydroxy-2-methyl-1,4-napthoquinone) is a naturally occurring antioxidant that exhibits an array of therapeutic attributes including anticancer effects against brain malignancies [222]

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